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Male hypogonadism should be diagnosed only if there are signs or symptoms of hypogonadism and total serum testosterone levels are low on at. These mental illnesses can be disabling to one's overall quality of life. Standard treatments like medications are not always effective and at least 70 percent. Effects of testosterone supplementation on depressive symptoms and sexual dysfunction in hypogonadal men with the metabolic syndrome. Giltay ej, tishova ya,. Many male patients with low to moderate levels of testosterone are being diagnosed with depression more often these days. While new research suggests that testosterone therapy could be used to treat depression in men, some experts are urging the use of caution. Depression is about twice as common in women as in men. Why is this? is it true? women are known to admit to a mental problem and seek. 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